Among nAChRs, receptors comprising the α 7 subunit are unique because of their high Ca2+ permeability and fast desensitization. However, the … Nicotine acts on both high-affinity nicotinic cholinergic receptors, such as the α4-β2 receptor, and low-affinity receptors, such as the α7 receptor, both centrally and peripherally. The nicotinic acetylcholine receptor (nAChR) belongs to a superfamily of pentameric ligand-gated ion channels involved in many physiologic and pathologic processes. https://www.tocris.com/pharmacology/nicotinic-alpha7-receptors Nicotine is the exogenous ligand of the nicotinic family of acetylcholine receptors (nAChR), members of a broader class of ligand-gated ion channels that includes GABA-A and serotonergic 5-HT3 receptors. Further analysis of the genes encoding the nicotinic acetylcholine receptors (nAChRs) has highlighted, in particular, the role of α 7 nAChRs in these higher order brain functions as evidenced by their peculiar physiologic and pharmacological properties. (1994) isolated cDNA and genomic clones coding for the human alpha-7 neuronal nicotinic receptor subunit, the major component of brain nicotinic receptors that are blocked by alpha-bungarotoxin. The CHRNA7 cDNA encodes a mature protein of 479 amino acids that is highly homologous to the rat alpha-7 neuronal nicotinic subunit (90%). Immunofluorescent analysis of HEK293 cells labeling Nicotinic Acetylcholine Receptor alpha 7 using ab216485 at 1/500 dilution, followed by secondary antibody Goat Anti-Rabbit IgG, Cy3 conjugated. Yi-Hua Qian contributed to the importance of alpha 7 nicotinic acetylcholine receptor and its effects on Alzheimer's disease, and the main parts of the manuscript, and Kai-Ge Ma contributes to the preparation, update and the revision of the manuscript and figures. University of Kentucky Doctoral Dissertations . Recent studies suggest that the alpha-7 nicotinic acetylcholine receptor (α7nAChR) may play a particularly prominent role in nicotinic effects on eating behaviors. Chini et al. woodcock, thomas matt, "modulation of the alpha-7 nicotinic acetylcholine receptor following experimental rat brain injury improves cellular and behavioral outcomes" (2010). All authors approved the final article. The -2 bp polymorphism or a nearby polymorphism of the NACHR alpha7 subunit may play a role in the pathogenesis of Bipolar Disorder. Alpha-7 nicotinic acetylcholine receptor agonist treatment reduces neuroinflammation, oxidative stress, and brain injury in mice with ischemic stroke and bone fracture J Neurochem . Receptors known to bind ACh include the nicotinic ACh receptors (nAChRs), which are present in the SVZ and have been shown to be important for cell proliferation, differentiation, and survival. Alpha-7 nicotinic acetylcholine receptor (α7-nAChR) agonists can prevent glutamate-induced excitotoxicity in cultured retinal ganglion cells (RGCs). DAPI staining of nuclei is shown too. 2014 Nov;131(4):498-508. doi: 10.1111/jnc.12817. alpha 7-Nicotinic acetylcholine receptors alpha 7-nAChRs play important roles in chemical and electrical signaling, and perhaps in neurite outgrowth, synaptic plasticity, and neuronal death/survival. 10, 11 In mammals, neuronal nAChRs are coded by 11 genes expressing receptor subunits (alpha2-alpha7, alpha9, alpha10, beta2-beta4).
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