Genetic variation in B-cell-activating factor is associated with an increased risk of developing B-cell non-Hodgkin lymphoma. This protein is best known for its role in the creation and maintenance of healthy B cells. (PMID: 19383901) Novak AJ ⦠Ansell SM (Cancer research 2009) 3 23 41; No evidence for an association between the -871 T/C promoter polymorphism in the B-cell-activating factor gene and primary ⦠[5] [6] BAFF is also known as B Lymphocyte Stimulator (BLyS) and TNF- and APOL-related leukocyte expressed ligand (TALL-1) and the Dendritic cell-derived ⦠B-cell activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. BAFF - B Cell-activating Factor Belonging To The TNF Family; BAFF - B Cell-activating Factor Of The Tumor Necrosis Factor Family; BAFF - Belonging To The Tumor Necrosis Factor Family; BAFF - B-Cell-Activating Factor B-cell activating factor. Buchanan R. , Popowych Y. , Dagenais C. , Arsic N. , Mutwiri G.K. , Potter A.A. , Babiuk L.A. , Griebel P.J. "B-Cell Activating Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).Descriptors are arranged in a hierarchical structure, which enables searching at ⦠Data are expressed as mean fluorescence intensity (MFI). Each symbol represents a single sample. Understanding the mechanisms that guide FVIII-specific B cell development could help identify therapeutic targets. 141 , ⦠B-Cell Activating Factor, BAFF, is a member of the tumor necrosis family, also known as TNF. The main biological function of BAFF in maintaining the maturation of B-cells to plasma cells has recently made it a target of the first FDA-approved selective BAFF antibody, belimumab, for the therapy of systemic lupus erythematosus. Allergy Immunol. Int Arch. Receptors present on a wide variety of hematopoietic and non-hematopoietic cell types that are specific for INTERLEUKIN-4They are involved in signaling a variety of immunological responses related to allergic INFLAMMATION including the differentiation of TH2 CELLS and the ⦠Serum B-cell maturation antigen (sBCMA) is the cleaved form of B-cell maturation antigen (BCMA), found at low levels in the serum of normal patients and generally elevated in patients with multiple myeloma (MM). "B-Cell Activating Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).Descriptors are arranged in a hierarchical structure, which enables searching at ⦠Information and translations of b-cell activating factor in the most comprehensive dictionary definitions resource on ⦠Schneider P, Takatsuka H, Wilson A, Mackay F, Tardivel A, Lens S, et al. Recent studies have underscored the role of B-cell-activating factor (BAFF), a member of the tumor necrosis factor superfamily, in promoting the survival of malignant B cells, including human multiple myeloma. Bâcellâactivating factor (BAFF) is a shortâterm survival factor for bursal cells. This protein acts as a member of the tumor necrosis factor (TNF) family with an essential role in peripheral B-cell homeostasis. B cell-activating factor (BAFF) is vital for B cell survival, proliferation, and maturation. Kang, J. S. et al. About B-Cell Activating Factor: B-Cell Activating factor is a protein, which is encoded by the human TNFSF13B gene. Changes in sBCMA levels have been found to correlate with a MM patientâs clinical status in response to treatment. We hypothesized that a rabies virus (RABV) ⦠B cell activating factor (BAFF) is a member of the tumor necrosis factor (TNF) superfamily of cytokines that links innate with adaptive immunity. doi: 10.1084/jem.194.11.1691 BAFF binds to 3 receptors that are primarily expressed on B cells: BAFF receptor (BAFF-R), B cell maturation ⦠Published: 08 May 2017 Graft-Versus-Host Disease. Maturation of marginal zone and follicular B cells requires B cell activating factor of the tumor necrosis factor family and is independent of B cell maturation antigen. Vet ⦠B cell activating factor (BAFF) is a pivotal factor for B cell survival, proliferation, and maturation . Gene. B-cell-activating factor (BAFF), also known as B-lymphocyte stimulator (BLyS), is a member of the tumor necrosis factor (TNF) superfamily: TNFSF 13b [48, 49]. ⦠We here characterized the functional significance of BAFF in the interaction between multiple myeloma and ⦠B Cell-Activating Factor Receptor (n.). (AâC) B cell activating factor-receptor (BAFF-R) expression on B cells and B cell subsets in pSS patients at baseline (n = 10) compared with healthy donors (n = 9). J Exp Med. BAFF signals through receptors on B cells, making it an attractive molecule to potentiate vaccine-induced B cell responses. Meaning of b-cell activating factor. Median values are represented by horizontal lines in each series. B-cell survival depends on signals induced by B-cell activating factor (BAFF) binding to its receptor (BAFF-R). The cytokine B cell activating factor (BAFF; also known as BLyS) plays an essential role in B cell survival and homeostasis. B-cell activating factor (BAFF) is a cytokine and adipokine of the TNF ligand superfamily. Unreviewed-Annotation score: -Experimental evidence at transcript level i. 1. B-cell activating factor (BAFF) plasma level at the time of chronic GvHD diagnosis is a potential predictor of non-relapse mortality positive regulation of B cell proliferation Source: AgBase "Interferon-gamma and B-cell Activating Factor (BAFF) promote bovine B cell activation independent of TLR9 and T-cell signaling." Ectopic lymphoid tissues (eLTs) characterized by B cell aggregation contribute to the local immunoglobulin production in nasal polyps (NPs). BAFF. Oryctolagus cuniculus (Rabbit) Status. In chronic obstructive pulmonary disease (COPD), lymphoid follicles have been associated with disease severity, and overexpression of BAFF has been demonstrated within lymphoid follicles of ⦠B cellâactivating factor (BAFF), also known as B lymphocyte stimulator (BLyS) and TNF ligand superfamily member 13B (TNFSF13B), is a cytokine belonging to the TNF ligand family that activates B cells (17, 18). B Cell Activating Factor, Renal Allograft Antibody-Mediated Rejection, and Long-Term Outcome Organism. Inhibitors to factor VIII (FVIII) remain the most challenging complication of FVIII protein replacement therapy in hemophilia A (HA). 83. Citations: Supplier Page Sign In or Register to view pricing. Analyzing BAFF-R expression and BAFF-binding to B cells in common variable immunodeficiency (CVID) patients, we ⦠B cell activating factor (BAFF) belongs to the tumor necrosis factor (TNF) cytokine family, shown first to play a key role in the maturation and survival of B lymphocytes and in the establishment of the humoral response (8, 9). (2001) 194:1691â7. Rationale: B cellâactivating factor (BAFF) plays a major role in activation of B cells and in adaptive humoral immune responses. Various cells can produce BAFF, including antigen-presenting cells, neutrophils, epithelial cells, and activated T lymphocytes. BAFF binds to 3 different receptors: BAFF-R, TACI, and BCMA. B-cell activating factor (BAFF) also known as tumor necrosis factor ligand superfamily member 13B is a protein that in humans is encoded by the TNFSF13B gene. Il B-Cell Activating Factor o BAFF, in italiano fattore attivante i linfociti B, anche conosciuto come ligando TNF appartenente alla superfamiglia 13B, è una proteina che negli uomini è codificata dal gene TNFSF13B.Il BAFF è anche conosciuto come uno stimolatore dei linfociti B (BLyS) e ligando espresso sui leuociti correlato con ⦠The expression levels of BAFF and its potential contribution to B cell maturation remain elusive in patients with tuberculous pleural effusion (TPE). BAFF receptor - Wikipedia TACI is currently being targeted for autoimmunity and B cell malignancies via atacicept, a recombinant fusion protein that binds the TACI ligands BAFF and APRIL. B cell Activating Factor/TNFSF13B (Human, Recombinant) is a high quality research product used as highly pure B cell Activating Factor/TNFSF13B (Human, Recombinant) expressed in CHO . B cell-activating factor is a novel diagnosis parameter for asthma. B-Cell Activating Factor ELISA Kit. Compare Product. The purpose of this study is to investigate whether BAFF is involved in the B cell ⦠B cellâactivating factors in autoimmune pulmonary alveolar proteinosis Masaki Hirose1, Toru Arai 1, Chikatoshi Sugimoto2, Takayuki Takimoto 2, Reiko Sugawara2, Shojiro Minomo2, Sayoko Shintani2, Naoko Takeuchi 2, Kanako Katayama2, Yasushi Inoue 2, Tomoko Kagawa 2, Takahiko Kasai 3, Masanori Akira4 and Yoshikazu ⦠B-cell activating factor (BAFF), also known as B-lymphocyte stimulator (BLyS), is an important growth factor for B cells. B-Cell Activating Factor; Detection Range: 78.125-5000pg/mL; Reactivity: Rat; Quantity: 96T; Reviews: Write a Review. Freshly isolated bursal cells were cultured with ( ) or without ( ) human BAFF recombinant protein (1 µg/ml) for 2â24 h, and viable cells were determined by fluorescenceâactivated cell sorter analysis. Interleukin 17 acts in synergy with B cell-activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus. Doreau A(1), Belot A, Bastid J, Riche B, Trescol-Biemont MC, Ranchin B, Fabien N, Cochat P, Pouteil-Noble C, Trolliet P, Durieu I, Tebib J, Kassai B, Ansieau S, Puisieux A, Eliaou JF, Bonnefoy ⦠B cell activating factor (BAFF), a member of the tumor necrosis factor family, is a key cytokine for B cell survival, a function that is essential for B cell maturation and memory. Function i GO - Molecular function i. tumor necrosis factor ⦠In mice, mutations in BAFF or BAFF-R cause B-cell lymphopenia and antibody deficiency. , Wilson H.L. BAFF deficiency leads to an almost complete loss of follicular and marginal zone B lymphocytes in mice ( 12 ). San Segundo et al., "B-cell-activating factor levels are associated with antibody-mediated histological damage in kidney transplantation," Transplantation Proceedings, vol.
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